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Published: 08 July 2022

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“Our research demonstrates that cannabis use in the general population is associated with heightened risk of clinically serious negative outcomes, specifically, needing to present to the ED [emergency department] or be admitted to hospital,” 

• Cannabis users were 22 percent more likely than those who don’t use to land in the emergency room or become hospitalized for any reason, suggesting use of the drug may be associated with negative health outcomes. 
• Bodily injury was the top reason for emergency department visits and hospitalizations among marijuana users, while respiratory issues came in second. 
• While recreational marijuana is still illegal in the U.S. under federal law, at least 19 states have passed legislation to allow sales of the drug.

(Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study | BMJ Open Respiratory Research)

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Published: 28 June 2022

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With the effect of cannabis on some of the parameters being studied for the first time in this study, the researchers discovered that cannabis had a detrimental effect on all of the visual parameters they assessed. 

Another study that investigated the effects of smoking cannabis on vision and driving performance also found that the visual effects of cannabis could impact driving performance, jeopardizing driving safety. Overall, it appears that information and awareness initiatives are critical for reducing the prevalence of cannabis-impaired driving.

Source: It's official. Smoking cannabis substantially alters the way you see (interestingengineering.com)

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Published: 28 June 2022

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Delta 8 THC Causing Cancer – Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study

From the Abstract Results indicate that between 8 and 20/34 cancer types were associated with Δ8THC exposure, with very high effect sizes (mEVs) and marginal effects after adjustment exceeding tobacco and alcohol, fulfilling the epidemiological criteria of causality and suggesting a cannabinoid class effect. The inclusion of pediatric leukemias and testicular cancer herein demonstrates heritable malignant teratogenesis. View Full-Text

Research published in https://www.mdpi.com/1660-4601/19/13/7726

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Published: 18 June 2022

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Epidemiological association of cannabinoid- and drug- exposures and sociodemographic factors with limb reduction defects across USA 1989–2016: A geotemporospatial study

Introduction: Limb reductions (LR) are rare and dramatic defects which were first described several thousand years ago in the literature of antiquity (Bermejo-Sanchez et al., 2011b, 2011a). More recently they received prominence as the hallmark and initial indication of the teratogenic action of the drug thalidomide (Bermejo-Sanchez et al., 2011b, 2011a). LR includes both absence of proximal limb elements (intercalary segments, phocomelia) as well as complete limb absence (amelia)

Highlights

• Limb reduction rates (LRR) were associated with cannabis use, and THC potency.
• A sharp increase in LRR rates occurred from the fourth to the fifth quintile.
• These relationships were robust to adjustment for ethic and economic covariates.
• They were maintained at geospatiotemporal regression.
• Cannabis legalization was associated with higher LRR's.

Conclusion: Therefore, a spatiotemporal and dose-dependent association between several cannabinoids including THC and cannabigerol and LRR is reported, is robust to adjustment, is consistent with pathophysiological and preclinical studies, accords with findings elsewhere, is markedly exacerbated in higher exposure quintiles, is exacerbated by cannabis legalization and evidences dose-related intergenerational sequaelae.

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