Get a Clue - Weed

Details: Published: 06 July 2023; Hits: 875

What Is HHC?

Hexahydrocannabinol, or “HHC,” is a cannabinoid, which are naturally occurring compounds in cannabis plants. Scientists have found more than 100 cannabinoids.

The most commonly known cannabinoids are Delta-9 THC and cannabidiol (CBD). THC is the ingredient in marijuana that makes you feel high. Cannabidiol is the ingredient in many CBD products that claim to help with everything from pain and soreness to anxiety, depression, and sleep problems. The FDA has not approved any THC drug for use in a medical setting.

There is one CBD product, Epidiolex, that the FDA approved for use with medical supervision to treat seizures in limited cases. There are also three FDA-approved synthetic cannabis-related products to treat nausea, vomiting, and loss of appetite. Beyond that, there is not enough evidence to know if these products are safe to use over the long term or whether they do what they say they do.

What Are the Dangers of Cannabinoids Like HHC?

Research is still emerging about the possible dangers of HHC. But scientists already are aware of possible issues that could take place when you use cannabinoid substances in a setting that is not medically supervised. Intoxicating cannabinoids like cannabis could lead to problems like:

Lowering your baby’s birth weight if you use them during pregnancy
Raising your risk of a car accident
Habitual use can make it hard to stop (cannabis use disorder) especially in teens
Negative effects on relationships and productivity at home, work, or school
Higher risk of injury in older adults
Dizziness on standing up, raising risk of passing out and falling
Raising mental illness risk in some people

For complete article go to WebMD - HHC

Details: Published: 06 July 2023; Hits: 841

Adverse childhood experiences are ‘strong predictor’ for adolescent cannabis use.

Young people who are exposed to adverse childhood experiences between the ages of 0 – 12 years, including parental drug misuse, are at highest risk for developing problematic adolescent cannabis use as teenagers, according to a new study.

Adverse childhood experiences (‘ACEs’) considered included physical, emotional and sexual abuse, emotional neglect, bullying, parental substance use, violence between parents, parental mental health challenges, and a parent being convicted of a criminal offence.

Risks for problematic adolescent cannabis use are highest for individuals reporting 4 or more ACEs, and were particularly raised for those with parental substance use or abuse

For complete article

(What are you modelling to your kids? Permission models such as legalisation of cannabis are only going to precipitate greater harms to already vulnerable Gen Now and Gen Next - #preventdontpromote)

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Details: Published: 06 July 2023; Hits: 838

Marijuana and the teenage brain.

Cognitive Effects: Detrimental
Academic Performance: Detrimental
Amotivational Syndrome: Detrimental
Dopamine Regulation: Detrimental
Social Withdrawal: Detrimental
Impact on Future Goals: Detrimental

Takeaways

The use of marijuana in adolescence can disrupt the normal development of the brain's endocannabinoid system.
Excessive marijuana use can disrupt dopamine balance in the brain, leading to a blunted reward response.
Raising awareness can help teens make informed decisions in support of their long-term goals.

For complete article

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Details: Published: 04 July 2023; Hits: 877

Development of cannabis use disorder in medical cannabis users: A 9-month follow-up of a randomized clinical trial testing effects of medical cannabis card ownership

Background: Evidence for long-term effectiveness of commercial cannabis products used to treat medical symptoms is inconsistent, despite increasingly widespread use.

Objective: To prospectively evaluate the effects of using cannabis on self-reported symptoms of pain, insomnia, anxiety, depression, and cannabis use disorder (CUD) after 12 months of use.

Conclusions: Frequency of cannabis use was not associated with improved pain, anxiety, or depression symptoms but was associated with new-onset cannabis use disorder in a significant minority of participants. Daily or near-daily cannabis use appears to have little benefit for these symptoms after 12 months of use.

For complete research

Details: Published: 27 June 2023; Hits: 998

Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study

Abstract: The use of Δ8THC is increasing at present across the USA in association with widespread cannabis legalization and the common notion that it is “legal weed”. As genotoxic actions have been described for many cannabinoids, we studied the cancer epidemiology of Δ8THC. Data on 34 cancer types was from the Centers for Disease Control Atlanta Georgia, substance abuse data from the Substance Abuse and Mental Health Services Administration, ethnicity and income data from the U.S. Census Bureau, and cannabinoid concentration data from the Drug Enforcement Agency, were combined and processed in R. Eight cancers (corpus uteri, liver, gastric cardia, breast and post-menopausal breast, anorectum, pancreas, and thyroid) were related to Δ8THC exposure on bivariate testing, and 18 (additionally, stomach, Hodgkins, and Non-Hodgkins lymphomas, ovary, cervix uteri, gall bladder, oropharynx, bladder, lung, esophagus, colorectal cancer, and all cancers (excluding non-melanoma skin cancer)) demonstrated positive average marginal effects on fully adjusted inverse probability weighted interactive panel regression. Many minimum E-Values (mEVs) were infinite. p-values rose from 8.04 × 10⁻⁷⁸. Marginal effect calculations revealed that 18 Δ8THC-related cancers are predicted to lead to a further 8.58 cases/100,000 compared to 7.93 for alcoholism and −8.48 for tobacco. Results indicate that between 8 and 20/34 cancer types were associated with Δ8THC exposure, with very high effect sizes (mEVs) and marginal effects after adjustment exceeding tobacco and alcohol, fulfilling the epidemiological criteria of causality and suggesting a cannabinoid class effect. The inclusion of pediatric leukemias and testicular cancer herein demonstrates heritable malignant teratogenesis.

Keywords: cannabis; cannabinoid; Δ8THC; teratogenesis; oncogenesis; carcinogenesis; cancer; cancerogenesis

For complete research