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Overall, investigators observed 22 and 31 DNA methylation markers associated with recent and cumulative marijuana use, respectively, from the first samples and 132 and 16 methylation markers in the second batch of samples, according to the study.
Many of the epigenetic changes were found in pathways previously linked to cellular proliferation, hormone signaling, infections and mental health disorders such as schizophrenia, bipolar disorder and substance use disorders, Hou said.
"In our study, we observed associations between cumulative marijuana use and multiple epigenetic markers across time," Hou said. "Interestingly, we consistently identified one marker that has previously been associated with tobacco use, suggesting a potential shared epigenetic regulation between tobacco and marijuana use. The observed marijuana markers were also associated with cell proliferation, infection and psychiatric disorders, however, additional studies are needed to replicate and verify these findings." (For full story (medicalxpress.com)
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(From) Abstract: Recent European data facilitate an epidemiological investigation of the controversial cannabis–cancer relationship. Of particular concern were prior findings associating high-dose cannabis use with reproductive problems and potential genetic impacts… Cannabis is a more important carcinogen than tobacco and alcohol and fulfills epidemiological qualitative and quantitative criteria for causality for 25/41 cancers. Reproductive and transgenerational effects are prominent. These findings confirm the clinical and epidemiological salience of cannabis as a major multigenerational community carcinogen.
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Cannabis & Youth Homelessness (for 16-25 y.o. homelessness) linked to cannabis use disorder: Homelessness is associated with cannabis use disorder more than all other drugs combined (including alcohol), Massachusetts General Hospital found in youth aged 16-25 years old experiencing homelessness. Rates of single and co-occurring psychiatric disorders and specific SUDs (cannabis use disorder [CUD] and alcohol use disorder [AUD]) were notably high. An increasing number of psychiatric diagnoses was significantly associated with elevated CUD/AUD prevalence and severity. Mood, anxiety, attention-deficit/hyperactivity, and antisocial personality disorders were siågnificåantly associated with elevated CUD/AUD prevalence and severity, as was suicidality (Source: American Academy of Child & Adolescent Psychiatry)
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Conclusions: Most studies on the effect of medicinal or recreational cannabis legalization/decriminalization on acute poisoning reported a rise in cannabis poisoning after legalization/decriminalization. (Source https://onlinelibrary.wiley.com/doi/10.1111/add.16280)
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Episode 7: Cannabis & Drug Demand Reduction Down Under (Dalgarno institute)
