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 Many people who use cocaine and other drugs return to drug use even after prolonged abstinence. Resumption of drug use often is driven by drug-associated memories that are retrieved when the person is exposed to drug cues. The results of a recent study in rats suggest that some neuronal connections (i.e., synapses) that encode cocaine-associated memories are not static but weaken for approximately 6 hours after they are retrieved and that holding these synapses in their weakened state may reduce return to cocaine use.

https://www.drugabuse.gov/news-events/nida-notes/2021/02/disrupting-cocaine-memories-prevents-return-cocaine-use-in-rats

(Dalgarno Institute Comment: It is important to note the ‘recalibrating’ of both brain and cellular memory is motivated by behavioural action, not chemical engagement  - See  also Humpty Dumpty Resiliency Ed. S. 6: Rebellion & Experimentation P2: From Thermometer to Thermostat (https://nobrainer.org.au/images/humpty-dumpty/RewardExploration_-_Part_Two.pdf )

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