Many people who use cocaine and other drugs return to drug use even after prolonged abstinence. Resumption of drug use often is driven by drug-associated memories that are retrieved when the person is exposed to drug cues. The results of a recent study in rats suggest that some neuronal connections (i.e., synapses) that encode cocaine-associated memories are not static but weaken for approximately 6 hours after they are retrieved and that holding these synapses in their weakened state may reduce return to cocaine use.
(Dalgarno Institute Comment: It is important to note the ‘recalibrating’ of both brain and cellular memory is motivated by behavioural action, not chemical engagement - See also Humpty Dumpty Resiliency Ed. S. 6: Rebellion & Experimentation P2: From Thermometer to Thermostat (https://nobrainer.org.au/images/humpty-dumpty/RewardExploration_-_Part_Two.pdf )